Correction: One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity

• Giovanna Bosica,
• Kaylie Demanuele,
• José M. Padrón and
• Adrián Puerta

Beilstein J. Org. Chem. 2021, 17, 2026–2027, doi:10.3762/bjoc.17.130

• 10.3762/bjoc.17.130 Keywords: antiproliferative activity; 1,2-dihydropyridines; green Hantzsch synthesis; heterogeneous catalysis; one-pot multicomponent reaction; The authors noticed that the E-factor (E) was calculated using a wrong Equation 2 in the original publication: The correct Equation 2 should

Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects

• Shivani Gulati,
• Stephy Elza John and
• Nagula Shankaraiah

Beilstein J. Org. Chem. 2021, 17, 819–865, doi:10.3762/bjoc.17.71

Three-component reactions of aromatic amines, 1,3-dicarbonyl compounds, and α-bromoacetaldehyde acetal to access N-(hetero)aryl-4,5-unsubstituted pyrroles

• Wenbo Huang,
• Kaimei Wang,
• Ping Liu,
• Minghao Li,
• Shaoyong Ke and
• Yanlong Gu

Beilstein J. Org. Chem. 2020, 16, 2920–2928, doi:10.3762/bjoc.16.241

• reactivity of aliphatic aldehydes, the reaction in Scheme 6 should be a wise choice for the synthesis of products similar in type to 5a. This point deserves further investigation. Conclusion In summary, an efficient and practical one-pot multicomponent reaction of (hetero)arylamines with α-bromoacetaldehyde

One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity

• Giovanna Bosica,
• Kaylie Demanuele,
• José M. Padrón and
• Adrián Puerta

Beilstein J. Org. Chem. 2020, 16, 2862–2869, doi:10.3762/bjoc.16.235

• preliminary study of the antiproliferative activity against human solid tumor cells demonstrated that 1,2-DHPs could inhibit cancer cell growth in the low micromolar range. Keywords: antiproliferative activity; 1,2-dihydropyridines; green Hantzsch synthesis; heterogeneous catalysis; one-pot multicomponent

• reaction; Introduction A multicomponent approach towards the synthesis of the desired product offers a number of advantages over a stepwise method. Such advantages include the development of a design that is: cheaper, simpler, economical, and environmentally friendly [1][2]. Multicomponent reactions are

An overview on recent advances in the synthesis of sulfonated organic materials, sulfonated silica materials, and sulfonated carbon materials and their catalytic applications in chemical processes

• Hashem Sharghi,
• Pezhman Shiri and
• Mahdi Aberi

Beilstein J. Org. Chem. 2018, 14, 2745–2770, doi:10.3762/bjoc.14.253

• homogeneous conditions (Scheme 5). After this successful application, catalyst 31 was tested in the synthesis of bis(2-amino-4H-pyran) derivatives 39–44 via a one-pot multicomponent reaction of dialdehydes 38 (instead of isatin and acenaphthenequinone substrates), a variety of C–H activated acids 20a,b, 23

Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction

• Manjunatha Narayanarao,
• Lokesh Koodlur,
• Vijayakumar G. Revanasiddappa,
• Subramanya Gopal and
• Susmita Kamila

Beilstein J. Org. Chem. 2016, 12, 2893–2897, doi:10.3762/bjoc.12.288

• . Conclusion In conclusion, the present work explores the use of 1,3-dipolar cycloaddition reactions for the regio- and stereospecific synthesis of functionalized spiropyrrolidines through a one-pot multicomponent reaction. This new route involving a vinyl framework gives rise to a wide array of novel

Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach

• Barbara Palka,
• Angela Di Capua,
• Maurizio Anzini,
• Gyté Vilkauskaité,
• Algirdas Šačkus and
• Wolfgang Holzer

Beilstein J. Org. Chem. 2014, 10, 1759–1764, doi:10.3762/bjoc.10.183

• assistance [17]. In view of the fact, that the two-step conversion 2→4a,b→5a,b was characterized by only moderate overall yields (59%, resp. 43%) it was considered to merge these two steps into a one-pot multicomponent reaction. The latter type of reaction attracts increasing attention in organic chemistry

Four-component reaction of cyclic amines, 2-aminobenzothiazole, aromatic aldehydes and acetylenedicarboxylate

• Hong Gao,
• Jing Sun and
• Chao-Guo Yan

Beilstein J. Org. Chem. 2013, 9, 2934–2939, doi:10.3762/bjoc.9.330

• day [28]. Thus we chose to employ a one-pot multicomponent reaction procedure to investigate our reaction. A mixture of dimethyl acetylenedicarboxylate, benzaldehyde, 2-aminobenzothiazole and excess piperidine in ethanol was stirred at room temperature for about twenty minutes and then was heated at